TNF Pathophysiology. Molecular and Cellular Mechanisms

TNF Pathophysiology
Molecular and Cellular Mechanisms

TNF Pathophysiology: Molecular and Cellular Mechanisms (Current Directions in Autoimmunity) [Hardcover] - G. Kollias (Editor), P. P. Sfikakis (Editor). TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. This book is mandatory reading for molecular and cell biologists, immunologists and clinicians interested in TNF function.

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Cellular and Molecular Neurophysiology, Third Edition

Cellular and Molecular
Neurophysiolgy

Cellular and Molecular Neurophysiology, Third Edition (Hammond, Cellular and Molecular Neurophysiology) [Hardcover] - Constance Hammond (Author). This third edition is the new, thoroughly revised edition of the only current, established and authoritative text focusing on the cellular and molecular physiology of nerve cells. Previously titled Cellular and Molecular Neurobiology, the new title better reflects this focus. The book is hypothesis driven rather than just presenting the facts, and the content is firmly based on numerous experiments performed by the top experts in the field. While the book does cover the important facts, it also presents the background for how researchers arrived at this knowledge to provide a context for the field. It teaches not only how excitable cells work in detail, but also how to construct and conduct intelligent research experiments. This book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. "In its third internationally acclaimed edition, this textbook provides an unrivaled account of the basic foundations of molecular and cellular neurophysiology.

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